| 综合强化干预措施提高美沙酮服用剂量效果分析 |
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| 引用本文： | 谷鸿秋,庞琳,刘恩武,殷文渊,罗巍,王常合,曹晓斌,柔克明,吴尊友. 综合强化干预措施提高美沙酮服用剂量效果分析[J]. 中国艾滋病性病, 2011, 0(6): 636-639 |
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| 作者姓名： | 谷鸿秋 庞琳 刘恩武 殷文渊 罗巍 王常合 曹晓斌 柔克明 吴尊友 |
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| 作者单位： | 北京协和医学院公共卫生学院;中国疾病预防控制中心性病艾滋病预防控制中心; |
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| 基金项目： | “十一五”“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项(2008ZX10001-016); 美国国立卫生研究院(NIH)中国艾滋病和结核病多学科培训项目(U2RTW006918)~~ |
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| 摘 要： | 目的评估综合强化干预措施提高美沙酮维持治疗(MMT)病人美沙酮服用剂量的效果。方法选取MMT门诊60个,分层配对后,以门诊为单位随机分配到干预组或对照组,在干预组实施综合强化干预措施,对照组为常规防治工作。采用混合效应模型以及多因素Logistic回归分析,评价综合强化干预对提高美沙酮服用剂量的效果。结果共入组6 631人,干预组3 797人,对照组2 834人。干预组美沙酮日均服用剂量从(64.1±35.4)mg/d提高到(68.9±38.2)mg/d,对照组美沙酮日均服用剂量从(61.4±33.6)mg/d提高到(63.3±34.1)mg/d,在控制了社会人口学等因素后,混合效应模型分析结果表明,美沙酮日均服用剂量在两组间的差异有统计学意义(F=48.69,P<0.0001)。干预组和对照组美沙酮日均服用剂量提高者所占比例分别为58.8%和53.5%(χ2=34.78,P<0.0001)。多因素Logistic回归分析表明,综合强化干预是提高美沙酮日均服用剂量有意义的影响因素(OR=1.236,95%CI:1.119～1.364)。结论综合强化干预措施对提高美沙酮服用剂量有一定效果,但是提高幅度有限,需要进一步分析原因。
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| 关 键 词： | 美沙酮维持治疗 随机对照干预试验 提高美沙酮剂量 效果评估 |
Effectiveness of integrated and intensified interventions on increasing methadone dose among clients of methadone maintenance treatment (MMT) in China |
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| GU Hong-qiu,PANG Lin,LIU En-wu,et al.. Effectiveness of integrated and intensified interventions on increasing methadone dose among clients of methadone maintenance treatment (MMT) in China[J]. Chinese JOurnal of Aids & STD, 2011, 0(6): 636-639 |
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| Authors: | GU Hong-qiu PANG Lin LIU En-wu et al. |
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| Affiliation: | GU Hong-qiu,PANG Lin,LIU En-wu,et al.(School of Public Health,Peking Union Medical College,Beijing 100730,China) |
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| Abstract: | Objective To evaluate the effectiveness of integrated and intensified interventions on increasing methadone dose among clients of methadone maintenance treatment(MMT) in China.Methods Sixty MMT clinics were selected,stratified by province,and matched by size and HIV prevalence,then were randomly assigned into intervention or control group.Integrated and intensified interventions were implemented in the intervention group and routine MMT services were provided in the control group.Mixed-effect model and mult... |
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| Keywords: | Methadone maintenance treatment Randomized controlled intervention trial Increasing methadone dose Effectiveness evaluation |
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