Aging, diazepam exposure and benzodiazepine receptors in rat cortex |
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Authors: | P.M. Reeves M.P. Schweizer |
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Affiliation: | aDepartment of Medicinal Chemistry, College of Pharmacy, University of Utah, Salt Lake City, UT 84112 U.S.A. |
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Abstract: | Densities of two benzodiazepine receptor subtypes (BDZ1 and BDZ2) in the frontal cortex of 10- and 27-month-old male Fischer-344 rats were nearly identical. Acute diazepam pretreatment produced a 73% increase in receptor density in the aged rats, mainly in the BDZ2 sites, whereas with the normal adult rat the density increased 42%, primarily due to stimulation of BDZ1 sites. Chronic exposure elicited similar increases of 28–29% in both normal and aged rats but there were subtle differences in the distribution of specific receptors. This study demonstrates a definite effect of age on the response of benzodiazepine receptors to diazepam pretreatment. |
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Keywords: | benzodiazepines BDZ1 and BDZ2 receptor subtypes triazolopyridine CL218,872 cortical receptors aging diazepam |
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