吲哒帕胺和苯那普利治疗高血压左心室肥厚的临床观察

目的观察吲哒帕胺和苯那普利对高血压合并左心室肥厚(LVH)患者的降压及逆转LVH的效果.方法选择100例轻、中度高血压合并LVH患者,随机分成3组,分别服用吲哒帕胺片(吲哒帕胺组)和苯那普利片(苯那普利组)及两药联用(联用治疗组),比较治疗前及治疗24周后坐位血压、动态血压(ABP)、左心室重量指数(LVMI)的影响.结果服药24周后吲哒帕胺组和苯那普利组及联用治疗组坐位血压分别平均下降15.06/13.65mmHg(1mmHg=0.133kPa)、14.91/13.21mmHg及20.85/17.21mmHg,白昼、夜间平均血压均有明显下降,LVMI分别平均减少8.29g/m2,8.12g/m2,16.03g/m2.结论吲哒帕胺与苯那普利均有较好的降压和逆转LVH作用,且两药联用效果更佳.

Clinical observation on left ventricular hypertrophy in hypertension patients treated with indapamide and benazepril

Objective: To observe the effects of indapamide and benazepril on left ventricular hypertrophy (LVH) and hypertension. Methods:One hundred patients with mild or moderate hypertension combined LYH were randomly divided into three groups and treated with indapamide, benazepril, indapamide plus benazepril respectively within 24 weeks. After tile therapy,the office blood pressure (OBP), ambulatory blood pressure (ABP) and left ventricular mass index (LVMI) were compared with those before therapy.Results:After 24-week-therapy, the mean decrease in OBP of indapamide group, benazepril group, indapamide plus benazepril group was 15.06/13.56 mmHg (1 mmHg=0.133 kPa), 14.91/13.21 mmHg and 20.85/17.21 mmHg respectively. Mean blood pressure dereased significantly in the day and at night. Mean decrease in LVMI of the three groups were 8.29 g/m2, 8.12 g/m2 and 16.03 g/m2 respectively. Conclusions:Both indapamide and benazepril are beneficial to the decrease of blood pressure and reversal of LVH, but the effect of combination therapy is better than that of single therapy.