Mitochondrial function, oxygen extraction, epicardial S-T segment changes and tritiated digoxin distribution after reperfusion of ischemic myocardium. |
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Authors: | J J Kane M L Murphy J K Bissett N deSoyza J E Doherty K D Straub |
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Institution: | From the Veterans Administration and the Department of Medicine, University of Arkansas School of Medicine, Little Rock, Ark., USA |
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Abstract: | This study examines the effect of 2 hours of reperfusion on transiently ischemic myocardium in pigs. Indexes of myocardial viability measured were mitochondrial function, oxygen extraction, epicardial S-T segment change and distribution of tritiated digoxin. Results were as follows: (1) Mitochondrial function was markedly impaired in the reperfused area after 60 minutes or more of coronary occlusion. The defect would seem to be a block in electron flow near site I, which can be partially bypassed with succinate. (2) An apparent inability of the reperfused myocardium to extract oxygen did not improve with 2 hours of reperfusion. (3) Epicardial S-T segment mapping suggested that necrosis occurred during reperfusion. (4) There was an altered distribution of tritiated digoxin in the reperfused area. The results show that reperfusion for 2 hours did not improve myocardial viability after 60 minutes or more of ischemia. |
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Keywords: | Address for reprints: James J Kane MD Veterans Administration Hospital 300 East Roosevelt Rd Little Rock Ark 72206 |
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