| 丹参对LDL受体及apoA－Ⅰ mRNA水平的影响 |
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| 引用本文： | 姜传仓,蔡海江,范乐明,李传富,王南,陈秀英. 丹参对LDL受体及apoA－Ⅰ mRNA水平的影响[J]. 南京医科大学学报(自然科学版), 1994, 0(4) |
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| 作者姓名： | 姜传仓 蔡海江 范乐明 李传富 王南 陈秀英 |
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| 摘 要： | 研究了丹参对高脂喂饲大鼠的血清脂质水平、肝低来度脂蛋白（ＬＤＬ）受体ｍＲＮＡ和载脂蛋白（ａｐｏ）Ａ－ＩｍＲＮＡ水平的影响，以及对培养的人成纤维细胞上述两种ｍＲＮＡ水平的影响。发现丹参能升高鼠肝及人成纤维细胞ＬＤＬ受体ｍＲＮＡ水平，但降血清总胆固醇及ＬＤＬ胆固醇作用不明显。提示ＬＤＬ受体可能存在翻译或翻译后水平的调节。丹参对鼠肝及人成纤维细胞ａｐｏＡ－１ｍＲＮＡ水平未见有影响。
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| 关 键 词： | 丹参；高胆固醇血症；低密度脂蛋白受体；载脂蛋白；基因表达；大鼠 |
Effects of Salvia Miltiorrhiza on Levels of LDL Receptor mRNA and apoA-I mRNA |
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| Jiang Chuancang,et al.. Effects of Salvia Miltiorrhiza on Levels of LDL Receptor mRNA and apoA-I mRNA[J]. Acta Universitatis Medicinalis Nanjing, 1994, 0(4) |
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| Authors: | Jiang Chuancang et al. |
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| Affiliation: | Atheroselerosis Research Center |
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| Abstract: | Effects of Chinese medicine,Salvia Miltiorrhiza on serum lipid levels,hepatic low density lipoprotein (LDL) receptor and apolipoprotein(apo) A-I mRNA levels were studied in cholesterol-loaded rats and cultured human fibroblasts. It was observed that Salvia Miltiorrhiza enhanced LDL recceptor mRNA levels in rat liver and in cultured human fibroblasts,but acted less effectively in lowering serum total cholesterol and LDL-cholesterol,suggesting translational or post-translational regulation of LDL receptor. No effects on apoA-1 mRNA levels of rat liver and human fibroblasts were noticed. |
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| Keywords: | salvia miltiorrhiza hypercholesterolemia LDL receptor apolipoprotein A1 gene expression rat |
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