生物材料生物相容性的分子水平评价研究

近二十多年来,以生物材料及其制品为基础的新高科技产业正在发达国家中悄然兴起,医用生物材料和人工器官的研究与生产也受到国际社会的极大关注并迅速发展起来,为临床医学的诊断与治疗开辟了新的途径。生物材料是材料科学与生命科学相互渗透和发展的必然产物,也是人类健全和完善自身机体和机能的又一有力武器。目前全世界有百余万人靠人工心瓣膜维持生命;约50万人靠人工肾生存;世界上所有的心脏直视手术都要靠人工心肺机支持;几乎所有的慢性病人都需要用一个可植入泵来释放药物,以保持一些特殊药物在特殊部位的特殊流率……[1]。所谓生物材…

The Evaluation of theBiocompatibility of Biomaterialat the Molecule Level

Rapid advances in the biotechnology field have led to the development of novel biomaterials with direct therapeutic applications, and biocompatibility remains the central theme for biomaterials applications in medicine. Molecular biocompatibility, which is a largely unexplored area of biomaterial research. may be defined as the assessment of cell responses to biomaterials at the molecular level. Here we introduce the current trends the techniques of molecular biology(PCR, ISH, et al .) provide us with sensitive indicators of reaction at the tissue biomaterial interface and play an important role in the evaluation of the biocompatibility of biomaterials.