An uncommon cause of acquired osteosclerosis in adults: hepatitis C-associated osteosclerosis |
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Authors: | Narendranath Epperla Fergus E. McKiernan |
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Affiliation: | 1. Department of Internal Medicine, Marshfield Clinic, 1000 N. Oak Ave, Marshfield, WI, 54449, USA 2. Center for Bone Disease, Marshfield Clinic, 1000 N. Oak Ave, Marshfield, WI, 54449, USA
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Abstract: | Hepatitis C-associated osteosclerosis (HCAO) is a rare sclerosing bone condition characterized by debilitating, predominantly lower extremity bone pain, accelerated bone turnover, and a generalized increase in histologically normal trabecular and cortical bone tissue. Herein we report the clinical presentation and imaging results of the 19th case of HCAO. Clinicians, particularly those caring for a population at risk for HCV infection, should be aware of this uncommon condition. The etio-pathogenesis of HCAO remains obscure but may bear important lessons in bone biology that could lead to new treatment options for osteoporosis. |
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