A Case of Small Cell Lung Cancer Successfully Treated with VM26 |
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| Authors: | SUGA, JUNJI SAIJO, NAGAHIRO SHINKAI, TETSU EGUCHI, KENJI SASAKI, YASUTSUNA SAKURAI, MASANORI SANO, TETSURO TAMURA, TOMOHIDE MORINAGA, SHOJIRO |
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| Affiliation: | Department of Internal Medicine, National Cancer Center Hospital Tokyo
*Pathology Division. National Cancer Center Research Institute Tokyo |
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| Abstract: | A 79-year-old man was admitted to our hospital for a close examinationof an abnormal shadow on a routine chest roentgenogram. A largetumorous shadow in the right S1 segment, and hilar and mediastinalnode swelling were observed. Transbronchial biopsy revealedthat the histologic type of the tumor was oat cell carcinoma.The clinical stage was considered to be limited disease. Becauseof his age, 79 years, he was treated with VM26 as a single agent.VM26 was administered by intravenous drip infusion of 60 mg/m2daily for five consecutive days every three to four weeks. Afterthe third course of treatment with VM26, he achieved partialresponse, and then radiation therapy to the primary site andthe hilar and mediastinal nodes was given at a total dose of6,000 rad. There have been few phase II studies of VM26 in patientswith small cell lung cancer (SCLC). Further phase II studiesshould be conducted for confirmation of the reproducibilityof the phase II study of VM26 in SCLC, and the efficacy of combinationchemotherapy including VM26 against SCLC should also be tested. |
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