冠心病血清超敏C-反应蛋白和血清淀粉样蛋白A，脂联素的关系

摘要：目的：探讨冠心病（CHD）患者血清超敏C-反应蛋白（hs-CRP）、血清淀粉样蛋白A（SAA）和血清脂联素（APN）的关系。方法：人选确诊冠心病的患者66例（CHD组），正常者20例（正常对照组）。分别测定其血清hs—CRP、SAA、APN水平，并进行比较。结果：CHD组hs—CRP、SAA水平分别为（2．88±0．61）mg／L和（9．89±5．23）mg／L，明显高于正常对照组的（0．67±0．17）mg／L和（1．27±1．11）mg／L，P均〈0．01；CHD组APN水平为（3．38±0．26）μg／L，显著低于正常对照组的（3．91±0．34）／Lg／L，P〈0．05。hs—CRP水平与SAA水平呈正相关（r=0．835，P〈0．05），与APN水平呈负相关（r=-0．285，P〈0．05）。结论：CHD患者血清hs—CRP、血清淀粉样蛋白A水平明显升高，血清脂联素水平明显降低，血清hs—CRP水平与淀粉样蛋白A水平呈正相关，与脂联素水平呈负相关，可作为临床诊断和预后判断的依据。

Relationship among serum highly sensitive C-reactive protein and serum amyloid A protein,adiponectin in patients with coronary heart disease

Objective： To discover the association among serum highly sensitive C--reactive protein （hs--CRP） and serum amyloid A protein （SAA）, adiponectin （APN） in patients with coronary heart disease （CHD）. Methods： A total of 86 persons were divided into CHD group （66 patients） and normal control group （20 persons）. Serum levels of hs--CRP, SAA and APN were measured in two groups. Results： Serum levels of hs--CRP and SAA in CHD group [ （2.88 ± 0.61） mg/L and （9.89 ± 5.23） mg/L ] were higher than those of normal control group [ （0. 67 ± 0.17） mg/L and （1.27± 1.11） mg/L, P〈0. 013; Serum level of APN inCHD group （3.28 ± 0.26） μg/L was less than that of normal control group （3.91± 0.34） μg/L, P〈0. 05. The level of hs--CRP was positively correlated with SAA （r=0. 835, P〈0. 05）; hs--CRP was negatively correlated with APN （r=-0. 285, P〈0.05）. Conclusion： Serum levels of hs--CRP and amyloid A protein increase while adiponectin decrease in patients with coronary heart disease. It may regard as index of diagnosing and predicting prognosis of coronary heart disease.