原发性肝细胞癌与乙型肝炎病毒X蛋白和p53

原发性肝细胞癌作为我国最常见的恶性肿瘤之一,其发生机制非常复杂,其中乙型肝炎病毒感染是其发生发展的重要原因,而乙型肝炎病毒X蛋白(HBx)在其中的作用尤为重要。HBx作为一种反式激活因子,其主要通过反式激活作用影响信号转导,抑制细胞DNA修复,影响细胞凋亡等导致肝癌发生;而p53基因作为抑癌基因,当发生突变时,突变型p53基因就可能导致肿瘤发生。近年来的研究也表明,HBx和p53之间的相互作用在肝癌的发生发展中也起到非常重要的作用。

Relationship of Hepatocellular Carcinoma with HBx and p53

Primary hepatocellular carcinoma is one of the common malignant tumors with complex pathogenesis,among which infection of hepatitis B is the important cause in its genesis and development,especially the effect of HBx is more important.HBx can affect signal transduction and cell apoptosis as well as inhibit cellular DNA repair mainly by transactivation as a kind of its factor,which will then result in the genesis of liver cancer. Gene p53 is akind of anti-oncogene,of which the mutation will result in genesis of tumor.Recent researches showed that interaction between HBx and p53 played very important role in the genesis and development of liver cancer.