| L-荷包牡丹碱对大鼠胃底肌条收缩效应的影响 |
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| 引用本文： | 李惠兰,张荣平,叶海涛,王红. L-荷包牡丹碱对大鼠胃底肌条收缩效应的影响[J]. 中国中药杂志, 2000, 25(7): 426-428 |
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| 作者姓名： | 李惠兰 张荣平 叶海涛 王红 |
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| 作者单位： | 昆明医学院药学系!云南昆明650031 |
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| 基金项目： | 云南省教委资助课题，云南省天然药物重点实验室资助 |
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| 摘 要： | 目的 :研究L-荷包牡丹碱 (L-D)对 5-HT ,Histamine,K+ ,Ca2+ 引起的大鼠胃底肌条收缩效应的影响。方法 :采用大鼠胃底肌条的离体实验法 ,观察L-D对其收缩效应的影响。结果 :L-D及罂粟碱 (pap)对 5 HT ,His tamine ,K+ 及Ca2+诱发的大鼠胃底肌条的收缩均有显著的对抗作用。呈现非竞争性拮抗。在无Ca2+ 液中两药均能抑制 5 HT诱发的收缩 ,提示两药对胃底肌条依赖细胞内Ca2+所致收缩均有显著的抑制 ,当恢复细胞外Ca2+ 浓度后 ,L-D对胃底肌条依赖细胞外Ca2+ 的收缩有抑制作用 ,而 pap无影响。 结论 :L-D具有松弛胃底肌条的作用。
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| 关 键 词： | L-荷包牡丹碱 胃底肌条 解痉 |
| 收稿时间： | 1999-09-09 |
Effect of L-Dicentrine on Contraction of Rat Stomach Muscle Strips |
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| LI Hui lan;ZHANG Rong ping;YE Hai tao;WANG Hong. Effect of L-Dicentrine on Contraction of Rat Stomach Muscle Strips[J]. China Journal of Chinese Materia Medica, 2000, 25(7): 426-428 |
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| Authors: | LI Hui lan ZHANG Rong ping YE Hai tao WANG Hong |
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| Affiliation: | Department of Pharmacology, Kunming Medical College, Kunming 650031, Yunnan, China. |
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| Abstract: | Objective:To study the effect ofL-dicentrine on the contraction of rat stomach muscle strips induced by 5-HT, histamine K+ and Ca 2+.Method:In vitro experimenting on rat stomach muscle strips.Results:The contraction of the strips induced by 5-HT histamine K+ and Ca2+ after high K+ depolarization was markedly inhibited by L-dicentrine or papaverine,showing a non competitive antagonism.The contraction induced by 5- HT was inhibited by L-dicentrine in Ca2+ free solution.L Dicentrine inhibited the contraction induced by 5-HT,depending on Ca2+ released from the intracellular store.When the Ca2+ concentration in both solutions was restored,L dicentrine did not influence the contraction significantly.Conclusion:L-Dicentrine could relax the rat stomach smooth muscle.In rat stomach smooth muscles there exist 5-HT receptors. |
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| Keywords: | L-dicentrine stomach smooth muscle relaxation |
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