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Cytogenetic remission with imatinib therapy in hypereosinophilic syndrome with trisomy 8 and resolution of severe cardiac dysfunction |
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| Authors: | Onitilo Adedayo A Kio Ebenezer A Singh Avtar K Lazarchick John |
| Affiliation: | a Department of Hematology/Oncology, Marshfield Clinic-Wausau Center, Wausau, WI, USAb Hematology/Oncology Division,c Department of Pathology and Laboratory Medicine, Ralph H. Johnson, Veterans Administration Medical Center, Charleston, SC, USAd Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA |
| Abstract: | We report a 50-year-old patient with idiopathic hypereosinophilic syndrome with trisomy 8 who experienced a complete and durable hematological and cytogenetic remission with low-dose imatinib therapy. He also had a significant reversal of cardiac dysfunction with a reduction in cardiac hypertrophy, resolution of pericardial effusion and mitral and tricuspid regurgitation. He remained in remission 3 years after therapy. |
| Keywords: | Cytogenetics hypereosinophilic syndrome imatinib tyrosine kinase FIP1-like-1-platelet-derived growth factor alpha (FIP1L1-PDGFRA) remission |
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