低剂量茶碱治疗慢性阻塞性肺疾病疗效观察

目的观察口服低剂量茶碱治疗中重度慢性阻塞性肺疾病（COPD）的效果。方法采用随机、单盲、安稳剂对照方法，选择中重度稳定期COPD患者61例，随机分为两组，观察组31例，对照组30例。观察组口服茶碱缓释片，对照组服用安慰剂，进行3个月实验，观察肺功能、生活质量的改善和不良反应发生的情况。结果观察组治疗后生活质量评分有改善（P〈0．002）、肺功能有轻到中度的改善（P〈0．05），不良反应少，对照组上述指标无改善。结论口服低剂量茶碱治疗中重稳定期COPD患者有较好的疗效，短期可改善肺功能。

Observation of the effect of low-dose theophylline in treatment of chronic obstructive pulmonary disease

Objective To observe the effect of low-dose theophylline in treatment of patients with moderate-severe chronic obstructive pulmonary disease(COPD). Methods This was a randomized,single-blind,placebo-controlled trial. Sixty-one patients with moderate-severe COPD were randomly divided into two groups: theophylline group(n=31) was treated with theophylline, control group (n=30) was given with placebo. The trial lasted for 3 months. Efficacy measures included lung function, quality of life scores,and adverse effects. Results Statistical improvements on quality of life scores(P<0.002) and lung function(P<0.05) were observed in the theophylline group. No improvement was observed in the control group. Drug-related adverse events were rarely found in the theophylline group. Conclusion Low-dose oral theophylline therapy is efficient in treatment of patients with moderate-severe stable COPD, which can improve lung function in short term.