Secondhand smoke exposure during pregnancy and infantile neurodevelopment |
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| Authors: | Lee Bo-Eun Hong Yun-Chul Park Hyesook Ha Mina Kim Ja Hyeong Chang Namsoo Roh Young-Man Kim Boong-Nyun Kim Yeni Oh Se-young Kim Young Ju Ha Eun-Hee |
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| Institution: | aDepartment of Preventive Medicine and Medical Research Institute, School of Medicine, Ewha Womans University, 911-1 Mok-6-Dong, Yangcheon-Gu, Seoul, Republic of Korea;bDepartment of Preventive Medicine, College of Medicine, Seoul National University, 28 Yeongeon-Dong, Jonro-Gu, Seoul, Republic of Korea;cDepartment of Preventive Medicine, Dankook University College of Medicine, 29 Anseo-Dong, Cheonan-Si, Chungcheongnam-Do, Republic of Korea;dDepartment of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine, 290-3 Jeonha-Dong, Dong-Gu, Ulsan, Republic of Korea;eDepartment of Nutritional Science and Food Management, Ewha Womans University, 11-1 Daehyun-Dong, Seodaemun-Gu, Seoul, Republic of Korea;fInstitute of Environmental and Industrial Medicine, Hanyang University, 17 Haengdang-Dong, Seongdong-Gu, Seoul, Republic of Korea;gDivision of Child and Adolescent Psychiatry, Department of Psychiatry and Institute of Human Behavioral Medicine, Seoul National University College of Medicine, 28 Yeongeon-Dong, Jongro-Gu, Seoul, Republic of Korea;hDivision of Child and Adolescent Psychiatry, Seoul National Hospital, 51 Neung-Dong-Ro, Gwangjin-Gu, Seoul, Republic of Korea;iDepartment of Food and Nutrition, Research Institute of Human Ecology, Kyung Hee University, Hoegi-Dong, Dongdaemun-Gu, Seoul, Republic of Korea;jDepartment of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, 911-1 Mok-6-Dong, Yangcheon-Gu, Seoul, Republic of Korea |
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| Abstract: | During prenatal development, the nervous system may be more susceptible to environmental toxicants, such as secondhand smoke. The authors assessed the effects of prenatal and postnatal secondhand smoke exposure on the neurodevelopment of 6-month infants. The subjects were 414 mother and infant pairs with no medical problems, taken from the Mothers' and Children's Environmental Health study. Prenatal and postnatal exposures to secondhand smoke were determined using maternal self-reports. Examiners, unaware of exposure history, assessed the infants at 6 months of age using the Bayley Scales of Infant Development. Bayley scores were compared for secondhand smoke exposed and unexposed groups after adjusting for potential confounders. Multiple logistic regression analysis was carried out to estimate the risk of developmental delay posed by SHS exposure. The multivariate model included residential area, maternal age, pre-pregnancy body mass index, education, income, infant sex, parity, birth weight, and type of feeding. After adjusting for covariates, secondhand smoke exposure during pregnancy was found to be related to a decrease in mental developmental index score, but not to a decrease in psychomotor developmental index score. In addition, secondhand smoke exposure during pregnancy was found to increase the risk of developmental delay (mental developmental index score ≤85) at 6 months. This study suggests that the infants of non-smoking women exposed to secondhand smoke are at risk of neurodevelopmental delay. |
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| Keywords: | Secondhand smoke Pregnancy Infant Neurodevelopment Cognitive function |
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