Progression of a sessile serrated adenoma to an early invasive cancer within 8 months |
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| Authors: | Oono Yasuhiro Fu Kuangi Nakamura Hisashi Iriguchi Yosuke Yamamura Akihiko Tomino Yasuhiro Oda Johji Mizutani Masaru Takayanagi Satoshi Kishi Daisuke Shinohara Tomoaki Yamada Kozo Matumoto Jun Imamura Kazuhiro |
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| Institution: | (1) Department of Gastroenterology, Tokyo Metropolitan Tama Cancer Detection Center, Tokyo, Japan;(2) Department of Coloproctology, Tokatsu-Tsujinaka Hospital, Chiba 270-1168, Japan;(3) Department of Gastroenterology, Chofu Surgical Clinic, 1-4-14, Kamiishihara, Chofu-shi, Tokyo 182-0035, Japan;(4) Department of Pathology, Tokyo Metropolitan Tama Cancer Detection Center, Tokyo, Japan;(5) Department of Surgery, Tokyo Metripolitan Fuchu Hospital, Tokyo, Japan |
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| Abstract: | Recent studies suggest that serrated polyps, including hyperplastic polyps, traditional serrated adenomas, and sessile serrated
adenomas, may be morphologically and genetically distinct and linked to microsatellite unstable colorectal cancers, and thus
the concept of a hyperplastic polyp–serrate adenoma–carcinoma pathway has been suggested. Furthermore, it has been suggested
that transformation from serrated polyps to invasive cancers can be rapid and occurs when the lesions are small; however,
direct evidence for this issue is scant. We herein describe a case of a sessile serrated adenoma showing rapid transformation
into a submucosal invasive carcinoma with remarkable morphological change in a short period of 8 months. This case is unique
and suggestive, as it provided information about the natural history of a sessile serrated adenoma. |
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| Keywords: | Sessile serrated adenoma Large hyperplastic polyp Invasive cancer Natural history Pit pattern Magnifying chromoendoscopy |
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