bFGF和硫糖铝对扩张后皮瓣成活长度及回缩率影响的实验研究

为观察bFGF和硫糖铝对扩张皮瓣成活长度及回缩率的影响 ,采用小猪制作持续扩张动物模型 ,同时注入bFGF加硫糖铝(实验Ⅰ组 )、bFGF加生理盐水(实验Ⅱ组 )和生理盐水 (对照组 )。扩张结束后第 3天制作扩张皮瓣和正常任意皮瓣。结果显示 ,实验Ⅰ组皮瓣存活长度大于对照组和正常任意皮瓣 (P <0 0 5 ) ,皮瓣早期回缩小于对照组 ,大于正常皮瓣 ,术后 8周皮瓣有增宽趋势 ;实验Ⅱ组与对照组比较差异无显著性意义。研究表明 ,bFGF和硫糖铝能增加扩张皮瓣的成活长度 ,降低皮瓣回缩率。

THE EFFECT OF LOCAL APPLICATION OF BFGF AND SUCRALFATE COMBINED WITH CTE ON VIABILITY AND STRETCH-BACK OF EXPANDED SKIN FLAP IN A PIG MODEL

To investigate the effect of bFGF and sucralfate on the improvement of the quality of expanded skin flap, white piglets were employed to establish a continuous tissue expansion model. They were randomly divided into 3 groups: group 1: both bFGF and sucralfate were injected; group 2: both bFGF and normal saline was injected; and group 3(the control group):only normal saline was injected. Three days after completion of the expansion ,normal and expanded skin flaps were created at random to assess flap viability and stretch back .The results showed that the flap survival length in group 1 was significantly larger than that of the control group and normal random flap( P <0 05). The flap stretch back of group 1 in the early stage was less than that of the control group but larger than that of the normal random flap. The expanded flap of group 1 was widening after 8 weeks. Group 2 showed no statistical difference as compared with the control group. It is suggested that local application of both bFGF and sucralfate during continuous tissue expansion(CTE) could improve the quality of expanded skin flap.