Protection from group B streptococcal infection in neonatal mice by maternal immunization with recombinant Sip protein |
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| Authors: | Martin Denis Rioux Stéphane Gagnon Edith Boyer Martine Hamel Josée Charland Nathalie Brodeur Bernard R |
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| Affiliation: | Unité de Recherche en Vaccinologie, Centre Hospitalier Universitaire de Québec et Université Laval, Ste-Foy, Canada. Denis.Martin@crchul.ulaval.ca |
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| Abstract: | The protective potential of antibodies directed against group B streptococcus (GBS) Sip surface protein was determined by using the mouse neonatal infection model. Rabbit Sip-specific antibodies administered passively to pregnant mice protected their pups against a GBS lethal challenge. In addition, active immunization with purified recombinant Sip protein of female CD-1 mice induced the production of specific antibodies that also confer protection to the newborn pups against GBS strains of serotypes Ia/c, Ib, II, III, and V. These data confirm that Sip-specific antibodies can cross the placenta and conferred protective immunity against GBS infections. |
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