Effect of thiamine hydrochloride on lead induced lipid peroxidation in rat liver and kidney |
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Authors: | Senapati S K Dey S Dwivedi S K Patra R C Swarup D |
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Affiliation: | Division of Medicine, Indian Veterinary Research Institute, Izatnagar. |
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Abstract: | Thiamine hydrochloride was studied on lead-induced endogenous lipid peroxidation in rat hepatic and renal tissues following po doses of 2.73 mg lead/kg bw for 6 w. Simultaneous use of 25 mg thiamine hydrochloride/kg bw po reduced lead accumulation in liver and kidneys. There were significant decreases in endogenous lipid peroxide in liver and kidney from thiamine hydrochloride-treated rats. Histopathological lesions in thiamine-treated livers and kidneys were milder in comparison to lesions in untreated Pb-exposed animals. This indicates the prophylactic potential of thiamine for lead-induced lipid peroxidation. |
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