Ketanserin causes surmountable antagonism of 5-hydroxytryptamine-induced contractions of large coronary arteries of dog |
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Authors: | Michael Frenken Alberto J. Kaumann |
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Affiliation: | (1) Institut für Experimentelle Chirurgie, Universität Düsseldorf, Universitätsstrasse 1, D-4000 Düsseldorf, Federal Republic of Germany;(2) Lehrstuhl für Klinische Physiologie, Universität Düsseldorf, Universitätsstrasse 1, D-4000 Düsseldorf, Federal Republic of Germany |
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Abstract: | Summary Large coronary arteries of the dog were contracted with 5-hydroxytryptamine (5-HT). The 5-HT2-receptor antagonist ketanserin antagonized the 5-HT-induced effects. Unlike Brazenor and Angus (Europ J Pharmacol 81: 569–576, 1982), who reported insurmountable antagonism of the effects of 5-HT in dog coronaries, we found that the antagonism by ketanserin can be surmounted, provided the concentrations of 5-HT are high enough. Ketanserin also unmasked a saturable component of the 5-HT-induced contractions. Although ketanserin (0.1–1 mol/l) depressed the maximal force of the saturable component, it did not change its EC50 (-log mol/l 8.0). We conclude that large coronary arteries of dog are contracted by 5-HT mainly though 5-HT2-receptors and to a smaller extent through receptors different from 5-HT2. |
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Keywords: | Dog large coronary artery 5-Hydroxytryptamine Ketanserin 5-HT2-receptors Surmountable antagonism |
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