| 依帕司他治疗糖尿病周围神经病变的临床观察 |
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| 引用本文： | 邓钰蕾,王瑛,陈生弟.依帕司他治疗糖尿病周围神经病变的临床观察[J].世界临床药物,2006,27(9):527-531. |
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| 作者姓名： | 邓钰蕾 王瑛 陈生弟 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院神经内科;上海交通大学医学院附属瑞金医院神经内科;上海交通大学医学院附属瑞金医院神经内科 |
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| 摘 要： | 目的观察依帕司他治疗糖尿病周围神经病变的有效性和安全性。方法30例糖尿病周围神经病变患者被随机分为依帕司他治疗组(15例)和甲钴胺治疗组(15例)。对比两组患者治疗前后自觉症状、神经功能及实验室检查结果的改善情况。结果治疗后4周,两组患者的主观症状均有改善,治疗后12周改善程度达到最大,但两组间改善程度无显著性差异(P>0.05)。结论依帕司他与甲钴胺疗效相当,且具有安全性高、耐受性良好的特点,可有效改善糖尿病周围神经病变的主观症状及体征。
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| 关 键 词： | 糖尿病神经病变 依帕司他 甲钴胺 |
| 文章编号： | 1672-9188（2006）09-527-05 |
| 收稿时间： | 2006-07-20 |
| 修稿时间： | 2006年7月20日 |
Clinical Study of Epalrestat in the Treatment of Diabetic Peripheral Neuropathy |
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| Deng Yu-Lei,Wang Ying,Chen Sheng-Di.Clinical Study of Epalrestat in the Treatment of Diabetic Peripheral Neuropathy[J].WORLD CLINICAL DRUGS,2006,27(9):527-531. |
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| Authors: | Deng Yu-Lei Wang Ying Chen Sheng-Di |
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| Institution: | Department of Neurology, Ruijin Hospital Shanghai Jiao Tong University, School of Medcine |
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| Abstract: | Objective To observe the efficacy and safety of epalrestat in the treatment of diabetic peripheral neuropathy. Methods 30 patients with diabetic peripheral neuropathy were randomly divided into 2 groups: epalrestat group(n=15) and mecobalamin group(n=15). The change of subjective symptom: neurological function and measuring results before and after treatment were compared between two groups. Result After four-week treatment, subjective symptoms were improved in both groups, and optimal improvement in subjective symptoms occurred after 12-week treatment, but there were no significant differences between two groups(P>0.05). Conclusion Epalrestat is safe and has similar effect on the treatment of diabetic peripheral neuropathy compared with mecobalamin. |
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| Keywords: | diabetic neuropathy epalrestat mecobalamin |
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