| ras基因突变与膀胱癌组织分化关系的研究 |
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| 引用本文： | 王振国,裘亚红,曾宪瑞. ras基因突变与膀胱癌组织分化关系的研究[J]. 吉林医药学院学报, 1999, 0(4) |
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| 作者姓名： | 王振国 裘亚红 曾宪瑞 |
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| 作者单位： | 吉林军医学院附属医院!吉林市132013(王振国，裘亚红)，衡阳医学院附属一院!衡阳421001(曾宪瑞) |
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| 摘 要： | 目的:探讨ras基困突变与膀胱癌组织分化之间的关系.方法:采用聚合酶链反应-单链DNA构象多态性分析法,对30例患者膀胱癌组织Ha-ras基因ExonⅠ点突变情况进行了检测.结果:膀胱癌组织分化Ⅰ级、Ⅱ级、Ⅲ级,其c-Ha-ras ExonⅠ点突变阳性率分别为25.0%、30.8%、88.9%,随癌组织级别升高,ras癌基因Exon Ⅰ点突变率明显增加,经X~2检验有显著性差异(P<0.01)结论:c-Ha-ras ExonⅠ点突变可以作为判断膀胱癌恶性程度的监测指标.
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| 关 键 词： | 癌 膀胱 突变 基因 组织学 |
On relationship between ras gene mutation and tissue differentiation in carcinoma of urinary bladder |
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| Wang Zhengguo,Qiu Yahong,Zen Xianrui Affiliated Hospital of Jilin Military Medical College,Jilin City. On relationship between ras gene mutation and tissue differentiation in carcinoma of urinary bladder[J]. Journal of Jilin Medical College, 1999, 0(4) |
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| Authors: | Wang Zhengguo Qiu Yahong Zen Xianrui Affiliated Hospital of Jilin Military Medical College Jilin City |
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| Affiliation: | Wang Zhengguo,Qiu Yahong,Zen Xianrui Affiliated Hospital of Jilin Military Medical College,Jilin City,132013 |
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| Abstract: | ve:To investigate the relationship between ras gene mutation and tissue differentiation in carcinoma of urinary bladder. Method:c-Ha-ras Exon I was detected by polymeras chain reaction product-single strand conformation polymorphism analysis on specimens of 30 bladder cancer cases. Result:The positive ratios of c-Ha-ras Exon I were 25.0 % , 30.8 % , 88.9 % respectively at tissue differentiation grades I , II and III in carcinoma of urinary bladder.The higher the grade, the higher the ratio of the mutation. Chi-sqaure test showed obvious difference ( P < 0.01). Conclusion: c-Ha-ras Exon I mutation can be regarded as a monitor index to decide the malignant degree of carcinoma of urinary bladder. |
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| Keywords: | cancer urinary bladder mutation gene histology |
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