依那普利联合氯沙坦用药对肾性高血压的影响

目的探讨依那普利联合氯沙坦用药对肾性高血压的影响。方法选择2008年1月～2009年12月我院收治的肾性高血压患者98例,随机分为观察组和对照组各49例。对照组给予依那普利,观察组在对照组基础上加用氯沙坦。观察两组对血压、肾功能的影响。结果观察组血压明显低于对照组,差异有显著性意义（t=4.31、3．98,P〈0．05）;观察组血压达标率（83．7％）明显高于对照组（61．2％）,差异有显著性意义（χ^2=6．19,P〈0．05）;观察组MAU、β2-M、BUN、SCr水平改善明显优于对照组,差异有显著性意义（t=4．18、3．95、4．65、4．12,P〈0．05）;两组不良反应发生率比较,差异无显著性意义（χ^2=0．49,P〉0．05）。结论依那普利联合氯沙坦用药可以发挥各自优势,起到协同作用,能够更有效降低血压,阻止或延缓肾脏疾病进展,且有良好的安全性,值得临床推广应用。

Drug effects of Enalapril and Losartan on renal hypertension

Objective To explore the drug effects of Enalapril and Losartan in treatment of renal hypertension.Methods Ninty-eighty patients with renal hypertension were randomly divided into observation group and control group of 49 cases in each January 2008 to December 2009 in our hospital.Control group was given enalapril,observation group were based on the use of losartan,the blood pressure and kidney function.were observed.Results Blood pressure was significantly lower in the observation group than in the control...