Increased expression of decorin during the regeneration stage of mdx mouse |
| |
Authors: | Shinichi Abe Daiki Hirose Syotaro Kado Osamu Iwanuma Hideki Saka Nobuaki Yanagisawa and Yoshinobu Ide |
| |
Institution: | (1) Department of Anatomy, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba, Chiba 261-8502, Japan;(2) Oral Health Science Center HRC7, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba, Chiba 261-8502, Japan;(3) Department of Oral Anatomy, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan |
| |
Abstract: | Satellite cells exist in postnatal muscle tissue and constitute the main source of muscle precursor cells for growth and repair.
These cells carry out important roles for skeletal muscle formation postnatally during growth of muscle mass as well as damage-induced
regenerative processes. Muscle regeneration supports muscle function in aging and has a role in the functional impairment
caused by progressive neuromuscular diseases. Major substances controlling this process are growth factors and extracellular
matrix. Myostatin, a member of TGF-β family, was mainly expressed in muscle tissue. Decorin, a member of the small leucine-rich
proteoglycan gene family, is composed of a core protein and a dermatan/chondroitin sulfate chain. Recent studies have shown
that decorin enhanced the proliferation and differentiation of myogenic cells by suppressing myostatin activity. Thus, decorin
appears to be a new molecule in the myostatin signaling pathway and a promising target for treatment of progressive neuromuscular
diseases. Therefore, in this study, we examined the localization of decorin as well as myostatin in a muscular dystrophy model
in mdx mice and B10 Scott Snells mice as a control to elucidate the differences between decorin and myostatin messages as
well as protein distribution. This study revealed increased expression of decorin protein as well as mRNA at the regenerative
stage of mdx mice compared to early stages, while only weak expression of decorin was detected in the control mice. Our study
contributes to identifying the relationship between decorin and myostatin as well as the development of a therapeutic strategy
for progressive neuromuscular diseases. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|