| 西替利嗪透皮贴剂的制备及药代动力学研究 |
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| 引用本文： | 曾春香,张斯汉,方云. 西替利嗪透皮贴剂的制备及药代动力学研究[J]. 中国现代药物应用, 2011, 5(11): 1-2 |
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| 作者姓名： | 曾春香 张斯汉 方云 |
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| 作者单位： | 1. 深圳市龙岗区人民医院,518172
2. 广州白云山制药股份有限公司 |
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| 摘 要： | 目的制备西替利嗪透皮贴剂并研究其药代动力学。方法用西替利嗪原料药及基质制备透皮贴剂,用家兔为实验动物研究其药代动力学。结果其Cmax（4.28±0.84）μg/ml,Tmax（24±5.69）h,T1/（28.34±2.67）h,AUC0→t（243.4±46.86）μg/（ml·h）,AUC0→∞（248.96±31.56）μg/（m·h）。结论西替利嗪透皮贴剂能成功控释药物,且工艺简单,实用性强。
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| 关 键 词： | 西替利嗪 贴剂 高效液相色谱 家兔 |
The preparation and pharmacokinetics research of Cetirizine transdermal patch |
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| ZENG Chun-xiang,ZHANG Si-han,FANG yun. The preparation and pharmacokinetics research of Cetirizine transdermal patch[J]. Chinese Journal of Modern Drug Application, 2011, 5(11): 1-2 |
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| Authors: | ZENG Chun-xiang ZHANG Si-han FANG yun |
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| Affiliation: | .Longgang Destrict Peoples Hospital of Shenzhen,Shenzhen 518172,China |
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| Abstract: | Objective To prepare cetirizine transdermal patch and invest its pharmacokinetics.Methods Crude drug of Cetirzine and ground substance were used for prepare letirizine.Pharmacokinetics were discussed by rabbits.Results Cmax（4.28±0.84）μg/（ml·h）,Tmax（24±5.69）h,T1/（28.34±2.67）h,AUC0→t（243.4±46.86）μg/（ml·h）,AUC0→∞（248.96±31.56）μg/（ml·h）.Conclusion Cetirizine transdermal patch can control release medichine,and has simple artwork and practicality. |
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| Keywords: | Cetirizine Patches High performance liquid chromatography Rabbit |
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