佛山地区呼吸机相关性肺炎病原学与细菌耐药性变迁的研究

目的：探讨佛山地区呼吸机相关性肺炎（VAP）病原学与细菌耐药性变迁状况。方法：将我市3家医院的120例VAP进行痰细菌培养及药敏试验,总结分析病原学与细菌耐药性变迁。结果：铜绿假单胞菌检出率在两年度均占首位,分别为21.33%及26.15%,并对头孢噻肟100%耐药,对亚胺培南也产生了严重耐药,耐药率由原来的0增至47.06%,对头孢哌酮/舒巴坦和头孢他啶的耐药率分别由原来的12.50%和25.00%增至52.49%和41.17%,对阿米卡星、左旋氧氟沙星和哌拉西林/他唑巴坦等药物的耐药率也不同程的增加;鲍曼不动杆菌和嗜麦芽假单胞菌两年度检出率分别为17.33%、16.92%和8.00%、12.34%,在两年内对多种抗生素的耐药性均有不同程度的增加;肺炎克雷伯菌和洋葱假单胞菌的检出率两年来出现下降趋势,真菌在两年度中仍具有较高的检出率,未发现耐药菌株。结论：各个细菌对抗生素的耐药谱不断发生变化,临床医师应及时掌握病原学及耐药性的变迁,并合理选择抗生素。

Study on etiology and bacterial drug resistance transition of ventilator associated pneumonia in Foshan area

Objective: To investigate the etiology and bacterial drug resistance transition of ventilator associated pneumonia in Foshan area.Methods: The phlegm with germiculture and the drug sensitive was tested in 120 cases with VAP in 3 hospitals,and the etiology and bacterial drug resistance transition were summerized.Results: The detection rate of pseudomonas aeruginosa in two years were 21.33% and 26.15%,and the resistance rate on Cefoperazone and Ceftazidime were raised from 12.50% and 25.00% to 52.49% and 41.1...