Defective phagocytosis confined to Staphylococcus aureus in a female infant with recurrent infections |
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Authors: | Setsuko Ito Haruki Mikawa Takao Hirao Takami Yoshida Rokuro Okuda |
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Institution: | (1) Department of Pediatrics, Kyoto University, Sakyo-ku, 606 Kyoto, Japan |
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Abstract: | Defective chemotaxis and phagocytosis of Staphylococcus aureus was identified in a female infant with marked hepatosplenomegaly and recurrent infections. Neutrophil mobilization from the marrow and marginal pool; random mobility; phagocytosis of yeast particles, latex beads and carbon particles; phagocytosis and intracellular killing capacity of Streptococcus pyogenes and E. coli; and NBT dye reduction were normal. Infiltration of neutrophils was depressed in the skin window test. The complement system and cellular immunity were intact. The patient also had a persistent EB virus infection.Defective phagocytosis limited to Staphylococcus aureus seems to be caused by an intrinsic cellular defect, such as congenital defect in neutrophil receptors for Staphylococcus aureus. |
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Keywords: | Phagocytosis Staphylococcus aureus Chemotaxis Hypergammaglobulinemia EB virus infection |
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