养阴活血方对鼻咽癌放疗减毒增效的临床观察

目的：观察中药养阴活血方对鼻咽癌放疗减毒增效的作用。方法：将100例初治鼻咽癌住院患者随机分为A、B两组，A组为中药养阴活血方配合常规放疗组50例，B组为单纯常规放疗组50例，观察两组的急性放射反应及放疗按时完成率、鼻咽原发灶及颈部肿大淋巴结的消退情况、放疗后1、3年生存率、复发率与转移率。结果：放疗后两组的口咽粘膜急性放射反应总的发生率基本相似，但A组的程度比B组轻，因此放疗按时完成率A组为98％，B组为84％（χ^2=4.40,P<0.05)。外照射剂量达50Gy时鼻咽原发灶消失率：A组为74％、B组为52％；前者高于后者（χ^2=4.29,P<0.05)。治疗后1、3年生存率两组比较差异无显著性。但两组3年生存者复发及转移率：A组为17.95%、B组为33.33%，组间比较差异有显著性（χ^2=4.92,P<0.05)。结论：中药养阴活血方配合鼻咽癌放疗可以减轻放疗反应，提高放疗按时完成率，从而减少放疗后复发及转移。

Clinical Observation on Effect of Nourishing-Yin and Activating-Blood Circulation Recipe in Reducing Toxicity and Enhancing Therapeutic Efficacy of Radiotherapy in Patients with Nasopharyngeal Carcinoma

To observe the effect of TCM recipe in nourishing-Yin and activating-blood circulation (NYAB) to patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy. Methods: One hundred patients with NPC receiving initial treatment were randomly divided into two groups, 50 in each group. Group A was treated with NYAB combined with conventional radiotherapy and Group B treated with conventional radiotherapy alone. The acute radioactive reaction, effect of radiotherapy, the 1-, 3-year survival rates, recurrence and metastasis rates were observed. Results: The total incidence of acute radioactive reaction of oral and nasopharyngeal membrane in the two groups were similar, but milder in Group A, so the in time accomplishment rate of radiotherapy in the two groups were 98% and 84% respectively, comparison between them, the difference was significant (X2 = 4.40, P<0.05). The nasopharyngeal primary lesion disappearance rate when the outer radiation dose up to 50 Gy in Group A was 74% and in Group B was 52%, the former was higher (^2 = 4.29, P< 0.05). The 1- and 3-year survival rate in the two groups was different insignificantly but the relapse and metastasis rate in patients that survived for 3 years in the two groups was 17.95% and 33.33% respectively with significant difference (X2 = 4.92, P<0.05). Conclusion: The combination of NYAB with radiotherapy could reduce the radiation reaction, elevate the in time accomplishment rate of the therapy, so as to reduce the relapse and metastasis after radiotherapy.