| 翼状胬肉中细胞增殖与凋亡相关基因蛋白的表达及其意义 |
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| 引用本文： | 郑卫东,徐国兴,胡建章,林雯,王婷婷. 翼状胬肉中细胞增殖与凋亡相关基因蛋白的表达及其意义[J]. 中国实用眼科杂志, 2003, 21(9): 649-651 |
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| 作者姓名： | 郑卫东 徐国兴 胡建章 林雯 王婷婷 |
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| 作者单位： | 福建医科大学附属第一医院福建省眼科研究所,350004 |
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| 基金项目： | 受福建省留学回国人员科研基金资助 (课题编号 :98J70 1 ) |
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| 摘 要： | 目的 :探讨增殖细胞核抗原 (PCNA)和抑凋亡基因Bcl 2、凋亡基因bax产物在翼状胬肉发病机理中的作用。方法 :应用SP免疫组织化学方法 ,检测 18例翼状胬肉、 9例正常结膜组织中PCNA、Bcl 2、bax基因产物的表达。结果 :PCNA在翼状胬肉中的阳性表达率显著高于正常结膜 (P <0 0 1) ,Bcl 2主要表达于翼状胬肉的上皮基底层细胞 ,正常结膜无表达 ,bax在翼状胬肉与正常结膜中的表达无显著差异。PCNA与Bcl 2表达呈正相关。结论 :翼状胬肉的发生、发展与PCNA和Bcl 2、bax的异常表达有关 ,可能是细胞异常增殖和凋亡失衡的共同结果。
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| 关 键 词： | 翼状胬肉 细胞增殖 细胞凋亡 相关基因蛋白 发病机理 增殖细胞核抗原 |
| 修稿时间： | 2002-12-01 |
Expression and significance of cell proliferation and apoptosis gene associated protein in pterygium |
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| ZHENG Weidong,XU Guoxing,HU Jianzhang,LIN Wen,WANG TingtingFujian ophthalmological institute,The First Hospital,Fujian Medical University,Fuzhou ,China. Expression and significance of cell proliferation and apoptosis gene associated protein in pterygium[J]. Chinese Journal of Practical Ophthalmology, 2003, 21(9): 649-651 |
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| Authors: | ZHENG Weidong XU Guoxing HU Jianzhang LIN Wen WANG TingtingFujian ophthalmological institute The First Hospital Fujian Medical University Fuzhou China |
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| Affiliation: | ZHENG Weidong,XU Guoxing,HU Jianzhang,LIN Wen,WANG TingtingFujian ophthalmological institute,The First Hospital,Fujian Medical University,Fuzhou 350005,China |
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| Abstract: | Objective:To study the roles of proliferating cell nuclear antigen(PCNA)?Bcl-2 gene and bax gene products in the pathogenesis of pterygium. Methods:The expression of Bcl-2?bax and PCNA were detected in 19 pterygium and 9 normal conjunctival specimens by immunohistochemical streptavidin peroxidases (SP) method. Results:The expression of PCNA in the pterygium was significantly higher than that of normal conjunctiva(P<0 01).Bcl-2 staining noted predominantly in the basal epithelial layer of cells,but normal conjunctival specimens showed no enidence of it.There was no difference in the expression of bax between pterygium and normal conjunctiva.The expression of PCNA was direct related to that of Bcl-2. Conclusions:The abnormal expression of PCNA and Bcl-2 may be a positive factor in the pathogenesis of pterygium.The results suggest that pterygia development may result from a co-operation of abnormal preliferation and unbalanced apoptosis. |
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| Keywords: | Pterygium Apoptosis PCNA Bcl-2 bax |
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