新诊断2型糖尿病患者亚临床大血管病变及危险因素分析

目的:研究新诊断2型糖尿病患者的亚临床大血管病变患病情况及危险因素分析。方法 :采取社区筛查、门诊收集的方法,获取178例新诊断2型糖尿病患者,行颈动脉彩色超声筛查亚临床大血管病变,并采集个人史、既往史、身高、体重、腰围及糖化血红蛋白(HbA1c)、血脂等数据。结果:178例患者中合并亚临床大血管病变者(A组)67例,患病率为37.6%,无亚临床大血管病变者(B组)111例(62.4%)。A组患者年龄较大,高血压患病率较高,且2组间高血压病程、收缩压差异具有统计学意义(P<0.05)。2组患者性别比例、吸烟率相似,腰围、腰臀比、舒张压、HbA1c、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇无明显差异,A组体质量指数(BMI)、总胆固醇(TC)水平较B组升高(P<0.05)。Logistic回归分析显示,高血压病史、BMI、TC是亚临床大血管病变患病的危险因素(P<0.05)。结论:部分新诊断2型糖尿病患者已合并亚临床大血管病变,高血压病程、BMI、TC是其患病的危险因素。

Prevalence and risk factors of sub-clinical large vessel disease in patients with newly diagnosed type 2 diabetes

Objective To study the prevalence and risk factors of sub-clinical large vessel disease in patiens with newly diagnosed type 2 diabetes(T2DM).Methods The patients(n=178) with newly diagnosed T2DM were divided into two groups according to results of carotid artery color ultrasonography.Data of present history,past history,height,weight,waist circumference,hemoglobin A1c(HbA1c),and serum lipid level were collected.Results Group A(n=67) had sub-clinical large vessel disease and group B(n=111) had no sub-clinical large vessel disease.There were significant differences in prevalence of hypertension,duration of hypertension,systolic blood pressure,the body mass index(BMI),total cholesterol(TC) between group A and group B(P<0.05),and no significant differences in gender,smoking,waist circumference,waist-hip ratio,diastolic blood pressure,HbA1c,triglyceride,high density lipoprotein cholesterol and low density lipoprotein cholesterol were found between group A and group B.Logistic regression analysis revealed that hypertension,BMI,TC were associated with risk of sub-clinical large vessel disease(β=1.370,P<0.05).Conclusions Duration of hypertension,BMI and TC were the risk factors of sub-clinical large vessel disease in patients with newly diagnosed T2DM.