| 高通量基因检测系统MammaPrint与乳腺癌预后预测 |
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| 引用本文： | 王波,LI Hong-sheng. 高通量基因检测系统MammaPrint与乳腺癌预后预测[J]. 中国癌症杂志, 2012, 22(1): 69-73 |
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| 作者姓名： | 王波 LI Hong-sheng |
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| 作者单位： | 广州医学院附属肿瘤医院乳腺肿瘤外科,广东广州,510095 |
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| 基金项目： | 广东省科技厅科技计划项目，广州市属高校科研重点攻关项目 |
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| 摘 要： | 化疗是乳腺癌患者术后最重要的辅助治疗手段.由于传统的临床病理指标不能准确预测患者复发风险,因此不能准确筛选出哪些患者需要化疗、哪些患者不需要化疗.高通量基因检测系统MammaPrint已被证实可较准确预测相当一部分乳腺癌患者复发风险,因而可用于指导个体化治疗.本文就MammaPrint的临床应用及研究现状作一综述.
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| 关 键 词： | MammaPrint 70-基因 基因表达谱 预后预测 乳腺癌 |
Gene expression profiling to predict the prognosis of breast cancer |
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| WANG Bo , LI Hong-sheng. Gene expression profiling to predict the prognosis of breast cancer[J]. China Oncology, 2012, 22(1): 69-73 |
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| Authors: | WANG Bo LI Hong-sheng |
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| Affiliation: | (Department of Breast Surgery,Affiliated Tumor Hospital of Guangzhou Medical College,Guangzhou Guangdong 510095,China) |
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| Abstract: | Chemotherapy is the most important postsurgery adjuvant therapy in the treatment of breast cancer.A major challenge is the selection of patients to determine who do require chemotherapy and who do not.The clinicopathological criteria is far from accurate for prediction of prognosis,causing a proportion of overtreatment.Using high throughput microarray analysis.MammaPrint which was identified can accurately divide patients into good and bad outcomes.The aim of this paper was to elaborate the research progress and its clinical utility for better understanding it. |
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| Keywords: | MammaPrint 70-gene Gene expression profiling Prognosis Breast cancer |
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