Stable coreceptor usage of HIV in patients with ongoing treatment failure on HAART. |
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| Authors: | Clara Lehmann Martin D?umer Ibrahim Boussaad Tobias Sing Niko Beerenwinkel Thomas Lengauer Norbert Schmeisser Christoph Wyen Gerd F?tkenheuer Rolf Kaiser |
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| Institution: | Department of Internal Medicine, University of Cologne, Germany. clara.lehmann@uni-koeln.de |
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| Abstract: | BACKGROUND: Disease progression in HIV infection has been associated with switch of viral coreceptor usage from CCR5 to CXCR4. OBJECTIVES: To investigate the relationship between HIV-coreceptor tropism and clinical and virological outcome in 40 heavily pretreated patients over time. METHODS: Coreceptor phenotype was predicted after sequencing the V3 loop of the HIV glycoprotein 120. RESULTS: Coreceptor use was stable during observation time in 87% of patients, and CCR5 tropism was predominant. Viral mutations in the pol gene and clinical parameters were not predictive for coreceptor switching. CONCLUSIONS: Even in patients with repeated HAART failure, CCR5 antagonists might be a valuable treatment option. |
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