Regional localization of aβ-galactosidase locus on human chromosome 22 |
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Authors: | J De Wit H L Hoeksema D Halley A Hagemeijer D Bootsma A Westerveld |
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Institution: | (1) Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands |
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Abstract: | Human white blood cells with an X/22 translocation 46, XX, t(X; 22)(q23; q13)] were fused with Chinese hamster cells. The isolated hybrids were analyzed for human chromosomes and 21 enzyme markers. An electrophoretic technique for studying the -galactosidase isoenzymes in man-Chinese hamster hybrid cells was developed. Immunological studies showed that the -galactosidase marker studied in these hybrids did contain immunological determinants of human origin. Furthermore the results provided evidence that a locus for -galactosidase is situated on chromosome 22 distal to the breakpoint in q13. |
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