两种短程三联方案治疗飞行员幽门螺杆菌阳性消化性溃疡疗效分析

目的研究呋喃唑酮(F)或甲硝唑(M)联用阿莫西林(A)及枸橼酸铋钾(C)1周疗法治疗飞行员幽门螺杆菌(Hp)阳性消化性溃疡的疗效。方法60例飞行员经胃镜证实惠有直径≥3mm的活动期消化性溃疡．随机分为治疗组和对照组，每组各30例。治疗组(CAF)给予呋喃唑酮0．1g，3／日；联用枸橼酸铋钾0．22g，2／日；阿莫西林1g，3／日。对照组(MAF)给予甲硝唑0．4g，3／日，联用枸橼酸铋钾0．22g，2／日；阿莫西林1g，3／日。疗程均为7日。结果溃疡愈合率，HP根除率治疗组分别为93％、93％，而对照组分别为76％、70%，两组比较差异有显著性。治疗1日、3日、7日缓解腹痛显效率治疗组分别为63％、90%、97％，对照组分别为53％、69％、76%，两组比较差异有显著性。两组均无严重不良反应，患者依从性较好。结论CAF疗法较MAF疗法疗效好，不良反应少，依从性好。是更理想的消化性溃疡治疗方案。

The analysis of two short term tripe therapy regimens for the degest ulcer of pliots with helico bacter pylori in fection

Objectives To study the efficacy of one week triple therapy with furazolidone or metironizole combined with am oxycillin and bismuth potassium citrate for the treatment of helicobacter pylori in fection in active degest ulcer.Methods 60 pilots cases of degest ulcer were randomly delivered to CAF group,in which patients were given bismuth potassium citrate 0.22 g bid+furazolidone 0.1 g tid +amoxycillin 1.0 g tid for one week,and MAF group as a control,in which patients were given bismuth potassium citrate 0.22g bid +metironizole 0.4g tid +amoxycillin 1.0 g tid for one week.Results ulcer cure rate and H.pylori eradication rate after CAF treatment were 93% and 93%,while 76% and 70% after MAF treatment.The relief rate of abdominal pain at 1 day,3 day and 7 day after CAF treatment were 63%,90% and 97%,while 53%,69% and 76% after MAF treatment.there were significant differences in ulcer cure rate,H.pylori eradication rate and the relief rate of abdominal pain between the two groups.there were no severe side effects in both group.Conclusions one week triple therapy of CAF appears to be more effective in active degest ulcer with helic obacter pylori in fection than that of MAF.CAF regimens seems to have better tolerance and compliance.