| The Expression of Estrogen Receptor is Dependent on the Estrogen Level and Associated with Cholesterol - Rich Diet in Female Rat''''s Heart and Vascular Endothelial Cells |
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| 引用本文： | 吴赛珠,刘建国,周可祥,刘长青,马瑞,孙飞,隗和明. The Expression of Estrogen Receptor is Dependent on the Estrogen Level and Associated with Cholesterol - Rich Diet in Female Rat''''s Heart and Vascular Endothelial Cells[J]. 岭南心血管病杂志(英文版), 2003, 0(1) |
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| 作者姓名： | 吴赛珠 刘建国 周可祥 刘长青 马瑞 孙飞 隗和明 |
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| 作者单位： | Department of Cardiology，Nanfang Hospital，Guangzhou 510515，P R China，Department of Cardiology，Nanfang Hospital，Guangzhou 510515，P R China，Department of Cardiology，Nanfang Hospital，Guangzhou 510515，P R China，Department of Cardiology，Nanfang Hospital，Guangzhou 510515，P R China，Department of Cardiology，Nanfang Hospital，Guangzhou 510515，P R China，Department of Cardiology，Nanfang Hospital，Guangzhou 510515，P R China，Atherosclerosis And Vascular Biology (AVB) Lab.，Johns Hopkins Singapore Pte Ltd |
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| 摘 要： | Objective To study the effects of estrogen level and cholesterol - rich diet on the expression of estrogen receptor (ER) in cardiovascular tissues including vascular endothelial cells (VEC) of female rats. Methods The receptor binding assay (RBA) was adopted to measure the estrogen receptor level in aortic wall, heart and vascular endothelial cells of female rats on a cholesterol - rich diet. A ra-dioimmunoassay was employed to measure the level of serum estradiol. Results The number of ER significantly decreased in hearts, aorta and vascular endothelial cells in the ovariectomized rats and the rats on a cholesterol - rich diet. In contrast, the administration of estrogen somewhat restored the expression of ER. Conclusions For female rats, the level of estrogen affects the expression of ER in cardiovascular system. The number of ER decreases along with the decrease in the level of estrogen. A cholesterol - rich diet also can decrease the expression of ER in cardiovascular system of female rats.
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The Expression of Estrogen Receptor is Dependent on the Estrogen Level and Associated with Cholesterol - Rich Diet in Female Rat''''s Heart and Vascular Endothelial Cells |
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| WU Saizhu LIU Jianguo,ZHOU Kexiang LIU ChangqingMA Rui,SUN Fei,WEI Heming. The Expression of Estrogen Receptor is Dependent on the Estrogen Level and Associated with Cholesterol - Rich Diet in Female Rat''''s Heart and Vascular Endothelial Cells[J]. South China Journal of Cardiology, 2003, 0(1) |
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| Authors: | WU Saizhu LIU Jianguo ZHOU Kexiang LIU ChangqingMA Rui SUN Fei WEI Heming |
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| Abstract: | Objective To study the effects of estrogen level and cholesterol - rich diet on the expression of estrogen receptor (ER) in cardiovascular tissues including vascular endothelial cells (VEC) of female rats. Methods The receptor binding assay (RBA) was adopted to measure the estrogen receptor level in aortic wall, heart and vascular endothelial cells of female rats on a cholesterol - rich diet. A ra-dioimmunoassay was employed to measure the level of serum estradiol. Results The number of ER significantly decreased in hearts, aorta and vascular endothelial cells in the ovariectomized rats and the rats on a cholesterol - rich diet. In contrast, the administration of estrogen somewhat restored the expression of ER. Conclusions For female rats, the level of estrogen affects the expression of ER in cardiovascular system. The number of ER decreases along with the decrease in the level of estrogen. A cholesterol - rich diet also can decrease the expression of ER in cardiovascular system of female rats. |
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| Keywords: | Aorta Estrogen receptor Heart Vascular endothelial cell |
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