| The changes of serum nitric oxide, angiotensin Ⅱ and superoxide anion in renal artery hypertension rat |
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| 引用本文： | 马向红,杨万松,黄体钢,周丽娟,倪燕平,樊振旺.The changes of serum nitric oxide, angiotensin Ⅱ and superoxide anion in renal artery hypertension rat[J].岭南心血管病杂志(英文版),2003,4(2):115-118. |
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| 作者姓名： | 马向红 杨万松 黄体钢 周丽娟 倪燕平 樊振旺 |
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| 作者单位： | The institute of cardiology，cardiology department of the second hospital of Tianjin medical university，Tianjin，300211，The institute of cardiology，cardiology department of the second hospital of Tianjin medical university，Tianjin，300211，The institute of cardiology，cardiology department of the second hospital of Tianjin medical university，Tianjin，300211，The institute of cardiology，cardiology department of the second hospital of Tianjin medical university，Tianjin，300211，The institute of cardiology，cardiology department of the second hospital of Tianjin medical university，Tianjin，300211，The institute of cardiology，cardiology department of the second hospital of Tianjin medical university，Tianjin，300211 |
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| 摘 要： | Objectives To study the changes of nitric oxide, angiotensin Ⅱ and superoxide anion in renal artery hypertension pathogenesis. Methods Male Wistar rats weighing 256 -285g were divided into 5 groups randomly, 10 rats of each group. Control group: false operation was made and routine diet was given; Ligature group: left renal artery was ligatured uncompletely and routine diet was given; Ligature + Losartan group: left renal artery was ligatured uneompletely and Losartan 20mg · kg~(-1) · d~(-1) was added in the drinking water; Ligature + L -Arg group: left renal artery was ligatured uncompletely and L -Arg 2g · kg~(-1) · d~(-1) was added in the drinking water; Ligature + L - Arg + Losartan group: left renal artery was ligatured uncompletely and L - Arg 2g· kg~(-1)· d~(-1) and Losartan 20mg · kg~(-1)· d~(-1) was added in the drinking water. Blood pressure and heart rate were measured before and at the end of the experiment. One week after ligature, blood was drawn to determine angiotensin Ⅱ, cGMP,
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| 关 键 词： | superoxide anion·nitric oxide hypertension·angiotensin Ⅱ |
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