| Cardioprotective Effect of Angiotensin n Receptor Antagonist on Perfused Ischemic Reperfusion Injury of Whole Isolated Rat Hearts |
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| 作者姓名： | 徐延敏 黄体钢 陈元禄 李广平 |
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| 作者单位： | Department of Cardiology of Second Hospital of Tianjin Medical University，Tianjin 300211，P R China，Department of Cardiology of Second Hospital of Tianjin Medical University，Tianjin 300211，P R China，Department of Cardiology of Second Hospital of Tianjin Medical University，Tianjin 300211，P R China，Department of Cardiology of Second Hospital of Tianjin Medical University，Tianjin 300211，P R China |
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| 摘 要： | Objectives Investigated the cardioprotective and mechanisms of losartan on whole isolated ischemic reperfused rat heart. Methods Langendorff perfused systems was used to investigate losartan effect on whole isolated rat hearts in CPK, LDH, MDA, SOD, ang II and arrhythmia. Results Losartan decreased incidence of arrhythmia, improved atrial ventricular block recovery in reperfu-sion period, during ischemic period, CPK and LDH in I/R group increased significantly compared with control group, 51. 33±27. 02 vs 22. 42 ± 13. 33, 31. 80 ±4.56 vs 22. 28 ± 15. 96, respectively, but greatly decreased in losartan group compared with I/R group, 23. 90±21.74 vs 51. 33 ±27. 02 and 11. 50 ±13. 20 vs 31. 80 ±4. 56, respectively. During reperfusion period CPK, LDH increased significantly in I/R group compared with control group, 49. 11 ± 20. 63 vs 12. 14 ±5.92 and 28. 70±4. 69 vs 23. 10±21. 38, respectively, but decreased greatly in losartan group compared with I/R group, 39. 40 ± 9. 60 vs 49. 11 ± 20.63 an
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Cardioprotective Effect of Angiotensin n Receptor Antagonist on Perfused Ischemic Reperfusion Injury of Whole Isolated Rat Hearts |
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| XU yanmin HUANG tigang CHEN yuanlu LI guangping.Cardioprotective Effect of Angiotensin n Receptor Antagonist on Perfused Ischemic Reperfusion Injury of Whole Isolated Rat Hearts[J].South China Journal of Cardiology,2003(1). |
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| Authors: | XU yanmin HUANG tigang CHEN yuanlu LI guangping |
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| Institution: | XU yanmin HUANG tigang CHEN yuanlu LI guangping
Department of Cardiology of Second Hospital of Tianjin Medical University,Tianjin 300211,P R China |
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| Abstract: | |
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| Keywords: | Ischemia - reperfusion Oxygen free radicals Angiotensin II receptor antagonist |
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