康妇炎胶囊对兔盆腔炎性疾病后遗症模型治疗的初步研究

目的利用盆腔炎性疾病(PID)后遗症模型初步探讨中药康妇炎胶囊对盆腔炎后遗症治疗的效果。方法采用逆行宫腔插管灌注细菌法建立兔PID后遗症模型19只,分为4组给药,空白对照组5只(对照组)、罗氏芬干预组5只(西药组)、罗氏芬+康妇炎胶囊干预组5只(混合组)、康妇炎胶囊干预组4只(中药组),观察模型血象、体重、静脉血急性期炎症因TNF-a、慢性期炎症因子TGF-β1、腹腔镜定期监测盆腔变化及子宫输卵管病理切片。结果中药组在急性期可观察到抑菌杀菌作用,但在急性期后期疗效不佳,难以抑制炎症进展;西药组在急性期有明显效果,后遗症期效果不显著,未改变PID结局;混合组在控制急性期和后遗症期PID均有较明显效果,可改善PID结局。结论中药康妇炎胶囊对PID急性期可抑菌杀菌;当与抗生素联合应用,在控制PID急性期和后遗症期均有较明显的效果。

Effect of kangfuyan capsule's on rabbit model of pelvic inflammatory disease

Objective To study the effect of kangfuyan capsule on the rabbit model of sequelae of pelvic inflammatory disease（PID）.Methods 19 PID rabbit models were divided into four groups：KC group was given kangfuyan capsule treatment alone（four rabbits）,AT group was treated with antibiotic（five rabbits）,AK group was treated with antibiotic and kangfuyan capsule（five rabbits）and control group（non-intervention）.The blood routine,body weight,levels of TNF-a and TGF-β1 were determined.Laparoscopic biopsy of the uterine and tube applied regularly to evaluate the effects.Results Kangfuyan capsule alone could inhibit inflammation but could not fully cure the acute pelvic inflammatory disease.Antibiotic treatment achieved satisfied effect in acute PID episode but not in chronic phase.Antibiotic plus Chinese medicine kangfuyan capsule improved the treatment effect significantly both in acute and chronic phase of PID.Conclusion Kangfuyan capsule has antibacterial effect during the acute phase,when given with antibiotic,it can improve the treatment effect of PID.