瑞舒伐他汀联合阿司匹林治疗颈动脉粥样硬化的临床观察

目的:观察瑞舒伐他汀联合阿司匹林治疗颈动脉粥样硬化的临床疗效和安全性。方法:150例颈动脉粥样硬化患者随机均分为A组、B组和C组。3组患者均给予低脂饮食等常规治疗。在此基础上,A组患者给予阿司匹林肠溶片100 mg,口服,每日1次;B组患者给予瑞舒伐他汀钙片10 mg,口服,每日1次;C组患者给予阿司匹林肠溶片(用法用量同A组)+瑞舒伐他汀钙片(用法用量同B组)。3组患者疗程均为6个月。观察3组患者临床疗效,治疗前后的血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、发生心脏缺血事件例数、劲动脉内中膜厚度(IMT)及不良反应发生情况。结果:C组患者总有效率显著高于A组及B组,3组比较差异有统计学意义(P<0.05)。治疗前3组患者TC、TG、LDL-C、HDL-C、发生心脏缺血事件例数、IMT比较,差异均无统计学意义(P>0.05);治疗后3组患者TC、TG、LDL-C、发生心脏缺血事件例数、IMT均显著低于同组治疗前,且C组低于A组及B组,差异均有统计学意义(P<0.05)。3组患者治疗期间均未见明显不良反应发生。结论:瑞舒伐他汀联合阿司匹林治疗颈动脉粥样硬化较单用瑞舒伐他汀或阿司匹林疗效更显著,安全性相似。

Clinical Observation of Atorvastatin Combined with Aspirin in the Treatment of Carotid Atherosclerosis

OBJECTIVE：To observe clinical efficacy and safety of atorvastatin combined with aspirin in treatment of carotid atherosclerosis. METHODS：150 patients with carotid atherosclerosis were randomly divided into group A,group B and group C. 3groups were all given low fat diet. Based on it,group A was additionally given Aspirin enteric-coated tablets 100 mg orally once a day;group B additionally received Rosuvastatin tablet 10 mg orally once a day;group C was additionally given Atorvastatin enteric-coated tablets（same usage and dosage as group A）and Rosuvastatin tablet（same usage and dosage as group B）. The treatment course of 3 groups lasted for 6 months,and clinical efficacies of 3 groups were observed. The serum total cholesterol（TC）triglyceride（TG）,low density lipoprotein cholesterol（LDL-C）,high density lipoprotein cholesterol（HDL-C）,carotid artery intima-media thickness（IMT）,case number of heart ischemia and the incidence of ADR were observed before and after treatment. RESULTS：The total effective rate of group C was significantly higher than that of group A and group B;there were statistically significant differences among 3 groups（P〈0.05）. Before treatment,there was no statistically significant difference in the levels of TC,TG,LDL-C and case number of heart ischemia,IMT among 3 groups（P〉0.05）;the levels of TC,TG,LDL-C,case number of heart ischemia,IMT in 3 groups after treatment were significantly lower than before;those of group C were lower than those of group A and B. that of group C was higher than that of group A and B; there was statistically significant difference（P〈0.05）. No obvious ADR was found in 3 groups during treatment. CONCLUSIONS：Atorvastatin combined with aspirin is more effective and safer than rosuvastatin or aspirin alone in the treatment of carotid atherosclerosis.