五味痔疮胶囊的镇痛、止血、通便和抗菌作用研究

目的:研究五味痔疮胶囊的镇痛、止血、通便和抗菌作用。方法:采用小鼠热板致痛和醋酸扭体实验观察五味痔疮胶囊的镇痛作用;采用小鼠断尾出血和体外凝血实验观察其止血作用;采用小鼠肠推进实验观察其通便作用;通过家兔肛门细菌性溃疡模型观察其抗菌作用。结果:1.68、0.84、0.42 g/kg剂量下,五味痔疮胶囊在给药30、90 min后可明显提高小鼠热板痛阈;1.68、0.84g/kg剂量下,五味痔疮胶囊可提高碳末在小鼠小肠的运行率;对冰醋酸所致扭体次数和出血、凝血时间虽有减少和缩短趋势,但差异均无统计学意义。0.482、0.241、0.121 g/kg剂量下,五味痔疮胶囊能明显改善细菌所致的家兔直肠黏膜层和肌层病理变化。结论:五味痔疮胶囊具有较好的镇痛、通便和抗菌作用。

Analgesic,Hemostasis, Catharsis and Antibacterial Effect of Five-taste Hemorrhoids Capsule

OBJECTIVE： To study the analgesic, hemostasis, catharsis and antibacterial effect of Five-taste hemorrhoids cap- sule （FTHC）. METHODS： The analgesic effects of FTHC were observed by the experiments of hot plate and acetic acid writhing response in mice. The hemostasis effects of FTHC were observed by docking bleeding and coagulation test in vitro. The catharsis ef- fect of FTHC was tested by the experiment of bowel moving facilitation in mice. The antibacterial effect of FTHC was evaluated by the model of bacterial ulcer in rabbit anus. RESULTS ： The pain threshold of mice could be significantly elevated 30 and 90rain af- ter administration of FTHC at the dose of 1.68,0.84 and 0.42. FTHC（1.68,0.84 g/kg） could obviously increase the running rate of carbon power in mice small intestine; FIHC could decrease the number of writhing induced by glacial acetic acid, shorten time of bleeding and clotting, there was not statistics significance. FTHC （0.482,0.241,0.12 l g/kg） could improve pathological changes in the mucous membrane and muscular layer of rabbit rectum induced by bacteria. CONCLUSIONS： FTHC has good analgesic, catharsis and antibacterial effect, and has certain hemostasis effect.