血清硫酸粘多糖片段检测在非小细胞肺癌的诊断价值

目的探讨血清硫酸粘多糖片段(SGF)检测在非小细胞肺(NSCLC)的诊断价值.方法对30例NSCLC患者和28例肺炎、慢性支气管炎患者应用乳胶凝集法测定血清中的SGF和用时间分辨荧光法测定血清中的癌胚抗原(CEA).结果NSCLC组血清SGF和CEA的阳性率明显高于肺炎、慢性支气管炎组(P＜0.01),且NSCLC组SGF的阳性率明显高于CEA(P＜0.05).SGF和CEA联合检测可使对NSCLC诊断的敏感性和准确性分别提高到83.3%和82.8%.结论血清SGF检测在NSCLC诊断中具有重要价值,其与CEA联合应用可提高对NSCLC的诊断率.

The Diagnostic Value of Detecting Serum Sulfate Glycosaminoglycan Fragments in Non-small Cell Lung Cancer

Objective To discuss the diagnostic value of detecting sulfate glycosaminoglycan fragments (SGF) in non-small cell lung cancer (NSCLC). Methods SGF and carcinoembryonic antigen (CEA) in serum from 30 patients with NSCLC and 28 patients with pneumonia or chronic bronchitis were measured by latex agglutination test and time-resolved fluorometry, respectively. Results The positive rates of SGF and CEA in serum from patients with NSCLC were significantly higher than those with pneumonia or chronic bronchitis (P<0.01). Furthermore, among NSCLC patients, the positive rate of SGF was significantly higher than that of CEA (P<0.05). By detecting SGF combined with CEA, the sensitivity and accuracy rose at 83.3% and 82.8% in the diagnosis of NSCLC, respectively. Conclusion Detecting serum SGF is a valuable method in the diagnosis of NSCLC. The combined detection of SGF with CEA can increase the diagnostic rate of NSCLC.