| 克拉霉素的体外抗菌作用 |
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| 引用本文： | 周乐,张敬德,吴培澄,陈友娣,施耀国,张婴元,刘裕昆. 克拉霉素的体外抗菌作用[J]. 复旦学报(医学版), 1995, 0(6) |
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| 作者姓名： | 周乐 张敬德 吴培澄 陈友娣 施耀国 张婴元 刘裕昆 |
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| 作者单位： | 上海医科大学华山医院抗生素研究所(周乐，张敬德，吴培澄，陈友娣，施耀国，张婴元)，上海医科大学华山医院抗生素研究所(刘裕昆) |
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| 摘 要： | 测试克拉霉素对166株临床分离的革兰阳性和阴性菌的体外抗菌活性,并与其他8种抗生素进行对比。克拉霉素对肺炎球菌的抗菌活性和红霉素相似,前者的MIC_(50)及MIC_(90)分别为0.015mg/L和0.01mg/L,后者的MIC_(50)及MIC_(90)分别为0.015mg/L和0.03/L。克拉霉素对非产酶金葡菌的作用比红霉素约强8倍。0.5mg/L的本品即能抑制90％的各组链球菌,对流感杆菌的抑菌率也高这95％。结果表明克拉霉素的抗菌作用明显优于其他大环内酯类抗生素。
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| 关 键 词： | 克拉霉素 红霉素 抗菌活性 |
THE IN VITRO ANTIMICROBIAL ACTIVITY OF CLARITHROMYCIN |
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| Zhou Le,Zhang Jingde,Wu Peichen,Chen Youdi,Zhang Yingyuan,Zhang Yingyuang,Liu Yukun. THE IN VITRO ANTIMICROBIAL ACTIVITY OF CLARITHROMYCIN[J]. Fudan University Journal of Medical Sciences, 1995, 0(6) |
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| Authors: | Zhou Le Zhang Jingde Wu Peichen Chen Youdi Zhang Yingyuan Zhang Yingyuang Liu Yukun |
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| Abstract: | The in-vitro activity of clarithromycin against 166 Gram positive and Gram negative clinical isolates was studied and compared with that of other 8 antibiotics including erythromycin. The in vitro activity of clarithromycin agaisnt ;Streptococcus pneumoniae was similar to that of erythromycin, MIC50 and MIC90 being 0.015mg/L and 0.08mg/L, respectively. The activity of clarithromycin against non-/3-lactamases producing Stapylococcus aureus was about 8 times higher than that of erythromycin. 90% of Streptococcus strains and 95% of Haemopilus influenzae strains could be inhibited by 0.5mg/L of the drug, The results indicate that the activity of clarithromyan is obviously better than that of other inacrolides tested. |
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| Keywords: | olarithromycin erythromycin in-vitro activity |
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