Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro |
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| Authors: | Ivan S. Ivanov Anastasia V. Sidehmenova Vera I. Smol’yakova Galina A. Chernysheva Mark B. Plotnikov |
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| Affiliation: | 1.E.D.Goldberg Institute of Pharmacology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia;2.Tomsk State University, Tomsk, Russia |
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| Abstract: | Objectives:To investigate the antiplatelet activity of alpha-lipoic acid (α-LA) and dihydroquercetin (DHQ).Materials andMethods: Antiplatelet activity of the α-LA and DHQ was evaluated in rich platelet plasma of rat. The platelet aggregation was induced by adenosine diphosphate (ADP) in concentration of 4 × 10-5 M.Results:α-LA and DHQ inhibited platelet aggregation in concentration-dependent manner. The antiplatelet activity of α-LA was more pronounced than DHQ. DHQ also increased the antiplatelet activity of α-LA by 1.4 times.Conclusion:Combined simultaneous use of α-LA and DHQ possessed the high antiplatelet activity, and DHQ potentiated the activity of α-LA.KEY WORDS: Alpha-lipoic acid, antioxidants, antiplatelet activity, dihydroquercetin, platelet aggregation |
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