Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample |
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| Authors: | Kerstin U. Ludwig Darina Roeske Johannes Schumacher Gerd Schulte-Körne Inke R. König Andreas Warnke Ellen Plume Andreas Ziegler Helmut Remschmidt Bertram Müller-Myhsok Markus M. Nöthen Per Hoffmann |
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| Affiliation: | Department of Genomics, Life and Brain Center, University of Bonn, Sigmund-Freud Str. 25, 53105, Bonn, Germany. |
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| Abstract: | The dyslexia susceptibility locus DYX2 (chr. 6p21-p22) harbours two candidate genes, DCDC2 and KIAA0319. In 2006, Harold et al. reported evidence for interaction between both genes. Having previously identified a risk haplotype for dyslexia in DCDC2, but not KIAA0319, in German families, we also tested for interaction between this risk haplotype and KIAA0319. We found a nominally significant association for the quantitative dimension “word reading”, the core phenotype in the study of Harold et al., which may be considered as supportive evidence. |
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| Keywords: | DYX2 Doublecortin domain Interaction Reading Spelling |
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