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Different antiarrhythmic effects of dalargin and β-endorphin in severe myocardial ischemia during stimulation of the sensorimotor cortex
Authors:S D Mikhailova  G I Storozhakov  A V Kudinova  T M Semushkina
Institution:(1) Russian State Medical University, Moscow
Abstract:The effects of the opiate receptor agonists dalargin and β-endorphin on the occurrence of idioventricular arrhythmias, including ventricular tachycardia and fibrillation, are studied in acute experiments on Nembutal-anesthetized cats. Dalargin administered in the dose crossing the blood-brain barrier produces a pronounced antiarrhythmic effect, while β-endorphin is effective only against ventricular fibrillation. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 7, pp. 28–31, July, 1997
Keywords:dalargin            β  -endorphin                      myocardial ischemia                      cardiac arrhythmia                      stimulation of sensorimotor cortex
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