A new cytotoxic amide from the stem wood of Hibiscus tiliaceus |
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Authors: | Chen Jih-Jung Huang Shi-Yu Duh Chang-Yih Chen Ih-Sheng Wang Tai-Chi Fang Hui-Yu |
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Institution: | Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung, Taiwan, ROC. |
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Abstract: | A new coumarin, hibiscusin, and a new amide, hibiscusamide, together with eleven known compounds including vanillic acid, P-hydroxybenzoic acid, syringic acid, P-hydroxybenzaldehyde, scopoletin, N- trans-feruloyltyramine, N-cis-feruloyltyramine, a mixture of beta-sitosterol and stigmasterol, a mixture of beta-sitostenone and stigmasta-4,22-dien-3-one were isolated from the stem wood of Hibiscus tiliaceus. The structures of these new compounds were determined through spectral analyses. Among the isolates, three compounds exhibited cytotoxicity (IC (50) values < 4 microg/mL) against P-388 and/or HT-29 cell lines in vitro. |
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