Production of monocyte chemoattractant protein-1 in amyotrophic lateral sclerosis |
| |
Authors: | Baron Pierluigi Bussini Simona Cardin Veronica Corbo Massimo Conti Giancarlo Galimberti Daniela Scarpini Elio Bresolin Nereo Wharton Stephen B Shaw Pamela J Silani Vincenzo |
| |
Institution: | Department of Neurological Sciences, Dino Ferrari Center, University of Milan Medical School, IRCCS Ospedale Maggiore Policlinico, Via S. Sforza 35, 20122 Milan, Italy. pierluigi.baron@unimi.it |
| |
Abstract: | The presence of activated microglia in the spinal cord of amyotrophic lateral sclerosis (ALS) patients is usually accompanied by inflammatory biochemical changes, but these are largely unexplored. Monocyte chemoattractant protein-1 (MCP-1) is critical for recruitment of inflammatory cells of monocytic lineage after inflammation or injury to the central nervous system. MCP-1 concentrations were measured by an enzyme-linked immunosorbent assay in the cerebrospinal fluid (CSF) and the serum of 27 patients with ALS and 30 patients with noninflammatory neurological diseases. In ALS, circulating MCP-1 levels were significantly increased in the serum and particularly in the CSF. Immunoreactivity for MCP-1 in ALS spinal cord was detected mostly in astrocytes but also in microglia, neurons, and within the vasculature of the cord. Our findings suggest a role for MCP-1 as an important molecular mediator of the injury response in ALS. |
| |
Keywords: | amyotrophic lateral slcerosis astrocytes chemokines inflammation microglia neurons spinal cord |
本文献已被 PubMed 等数据库收录! |
|