Paget's disease, workup and monitoring |
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| Authors: | Roux Christian |
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| Institution: | 1. Centre hospitalier inter-communal de Poissy Saint-Germain, 10, rue Champ-Gaillard, 78303 Poissy cedex, France;2. Service de gynécologie endocrinienne et médecine de la reproduction, hôpital Jeanne-de-Flandre, centre hospitalier régional universitaire de Lille, avenue Eugène-Avinée, 59037 Lille cedex, France;3. Service de gynécologie médicale, orthogénie et médecine du couple, hôpital Jeanne-de-Flandre, centre hospitalier régional universitaire de Lille, avenue Eugène-Avinée, 59037 Lille cedex, France;1. Service d’ophtalmologie, hôpitaux universitaires, université de Hacettepe, Ankara, Turquie;2. Département de pathologie, faculté de médecine, université de Hacettepe, Ankara, Turquie;1. Service d’ORL et chirurgie cervicofaciale, CHU La Conception, AP–HM, 147, boulevard Baille, 13005 Marseille, France;2. Département de médecine interne, CHU La Timone, AP–HM, 13005 Marseille, France;3. Service d’ORL et chirurgie cervicofaciale, HIA Sainte-Anne, 83000 Toulon, France;1. Department of Orthopaedics and Trauma, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4SA, United Kingdom;2. Southmead Hospital, Southmead Road, Bristol, BS10 5NE, United Kingdom;3. University of British Columbia, Vancouver, V5Z 1M9, Canada;1. Service de médecine nucléaire, hôpital Tenon, Assistance publique–Hôpitaux de Paris, 4, rue de la Chine, 75020 Paris, France;2. Service de médecine nucléaire, hôpital Lariboisière, Assistance publique–Hôpitaux de Paris, 2, rue Ambroise-Paré, 75010 Paris, France |
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| Abstract: | Paget's disease is a progressive bone disease, characterized by bone hypertrophy and increased bone resorption. The pain and deformity that characterize its clinical course are not simple to assess, but it has a characteristic radiographic appearance. In most cases, treatment can be monitored through biological markers of bone turnover. Total alkaline phosphatase is the best marker and measurement of collagen breakdown products is useful in difficult cases. The goal of treatment is the normalization of these biological markers, to prevent complications of the disease. |
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