| Abstract: | In experimental pancreatitis induced by a modified method (Arai, 1965) 5-fluorouracil has a marked therapeutic action, preventing the development of necrosis of the acini and suppurative liquefaction of the gland tissue. The authors attribute the therapeutic effect of 5-fluorouracil to its inhibitory action on RNA synthesis and blockade of the liberation of secretion from the exocrine part of the pancreas.Department of Abdominal Surgery and Department of Surgical Anatomy, A. V. Vishnevskii Institute of Surgery, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR N. A. Kraevskii.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 89, No. 3, pp. 366–368, March, 1980. |
