| 脂质体携载超氧化物歧化酶对离体大鼠心脏模拟缺血—再灌注损伤的治疗作用 |
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| 引用本文： | 谢国风,唐朝枢,苏静怡. 脂质体携载超氧化物歧化酶对离体大鼠心脏模拟缺血—再灌注损伤的治疗作用[J]. 基础医学与临床, 1989, 0(5) |
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| 作者姓名： | 谢国风 唐朝枢 苏静怡 |
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| 作者单位： | 北京医科大学病理生理教研室(谢国风，唐朝枢)，北京医科大学病理生理教研室(苏静怡) |
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| 基金项目： | 国家科委“七五”攻关资助项目 |
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| 摘 要： | 磷脂脂质体作为载体包裹超氧化物歧化酶(SOD)治疗离体大鼠心脏缺血-再灌注损伤,明显抑制脂质过氧化物形成,减轻心肌组织蛋白漏出,减少钙离子在缺血心肌的聚积,其疗效显著优于单用SOD或SOD加空白脂质体治疗。实验结果提示脂质体作为药物载体治疗心肌缺血是有前途的。
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Protective Action of Liposome Entrapped Superoxide Dismutase Against Ischemia-reperfusion Damage of Isolated Rat''''s Heart |
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| Xie Guofeng Tang Chaoshu Su Jingyi. Protective Action of Liposome Entrapped Superoxide Dismutase Against Ischemia-reperfusion Damage of Isolated Rat''''s Heart[J]. Basic Medical Sciences and Clinics, 1989, 0(5) |
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| Authors: | Xie Guofeng Tang Chaoshu Su Jingyi |
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| Affiliation: | Department of Pathophysiology Beijing Medical University |
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| Abstract: | Superoxide dismutase (SOD) entrapped in phospholipid liposomes used in the treatment of ischemia-reperfusion damage of isolated rat's heart significantly inhibited heart lipid peroxidation, ameliorated the protein leakage from ischemic myocardium and the accumulation of Ca2+ in myocardium. The therapeutic effect of liposomes entrapped SOD was significantly better than that of SOD alone or SOD plus liposomes. The results suggest that lipsome as a kind of drug carrier might be very useful in the treatment of myocardial ischemia. |
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| Keywords: | liposome SOD myocardial ischemia-recerfusion |
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