河南汉族部分人群vWA和FESFPS基因座遗传多态性观察

目的；研究河南地区部分汉族人群中vWA和FESFPS基因座遗传多态性，获得vWA和FESFPS基因座的群体遗传学数据。方法：应用聚合酶链反应（PCR)矣丙烯酰胺凝胶电泳分型方法，分别观察河南地区228例无血缘关系汉族人的vWA和FESFPS基因座的基因型分布。结果：河南地区汉族群体中vWA基因座存在8个等位基因，杂合度为0.7666，个人识别能力为0.8913，非父排除率为0.543。FESFPS基因座存在7个等位基因，杂合度为0.7777，个人识别能力为0.7008，非父排除率为0.4603,2个位点基因型分布均符合Hardy-Weinberg平衡。结论：vWA和FESFPS位点均是高杂合度，高鉴别能力的遗传标记系统，具有较高的法医学应用价值。

Genetic polymorphism at vWA and FESFPS loci for partial Han People in Henan Province

Aim:To study the genetic polymorphism at vWA and FESFPS loci for partial Han people in Henan Province and to obtain population genetic data for vWA and FESFPS loci. Methods: Multiplex PCR technique and PAGE electrophoresis were used to detect the genotype frequencies of vWA and FESFPS loci for 228 cases of Han People without kinship.Results: Eight alleles of vWA and 7 alleles of FESFPS were identified. The expected heterozygosity of vWA and FESFPS were 0.766 6 and 0.777 7, respectively. The discrimination power (DP) was 0.891 3 for vWA and 0.700 8 for FESFPS. The power exclusions (PE) was 0.543 for vWA and 0.460 3 for FESFPS. The genotypes of both loci were accorded with Hardy Weinberg equilibrium. Conclusion: The results show that vWA and FESFPS loci are valuable genetic marker system in the areas of forensic medicine and genetics.